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Spliceosome
According to the
current model of pre-mRNA splicing, the five
splicing snRNPs (small nuclear
ribonucleoproteins) are thought to assemble on
the pre mRNA, forming a
large ribonucleoprotein complex called a
spliceosome (Protein-RNA complex that removes
introns in eukaryotic nuclear RNAs.), named by
J. Abelson and E. Brody. The splicing apparatus
in eukaryotic messenger RNAs consists of several
components called small nuclear
ribonucleoproteins (discovered and named by J.
Steitz and colleagues), abbreviated as snRNPs
and pronounced “snurps.” Five of these particles
take part in splicing, each composed of one or
more proteins and a small RNA molecule; they are
designated U1, U2, U4, U5, and U6.
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